9/24/2008 PERMALINK
Inhibiting Lp-PLA2 protein prevents blockage of your arteries Elevated levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) in your blood predict an increased risk of heart disease events and are related to the development of plaques. Darapladib specifically inhibits Lp-PLA2. "The results are exciting," says Robert L. Wilensky, MD. "First, darapladib reduced the overall amount and size of plaques that block the coronary arteries of animals in the study. More importantly, it reduced the number and size of the type of advanced plaques that cause heart attacks and strokes." ... University of Pennsylvania Health System